Instructions

This medicine is given as an IV injection into a vein.

This medicine should be given over 30 minutes.

Read and make sure you understand the instructions for measuring dose and using syringe. If you have any questions, talk to your doctor, nurse, or pharmacist.

The medicine needs to be mixed before being injected.

Always inspect the medicine before using.

The liquid should be clear or light yellow.

Do not use the medicine if it contains any particles or if it has changed color.

Gently swirl to mix the medicine. Do not shake.

Store at room temperature or in refrigerator. Do not freeze. Protect from light.

Keep the medicine in its original container.

Do not store above 77 degrees F (25 degrees C).

Never use any medicine that has expired.

Discard any unused, mixed medicine after 48 hours.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Tell your doctor or nurse right away if any of these happen while the medicine is being given: chest pain, pounding heartbeat, wheezing or trouble breathing, dizziness, feeling of heat or flushing, back pain, swelling of the lips, nausea or vomiting, or rash. The medicine may need to be stopped or given at a slower rate.

Do not use the medication any more than instructed.

Contact your doctor if you notice a change in the amount or darkening of your urine.

Speak with your health care provider before receiving any vaccinations.

Please tell your doctor if you have moderate to severe diarrhea while on this medicine. Do not treat the diarrhea with over-the-counter diarrhea medicine.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

Ask your pharmacist how to properly throw away used needles or syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• diarrhea
• headaches
• pain, redness, swelling near injection
• nausea
• yeast infection of mouth
• vaginal itching or yeast infection

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• severe, watery or bloody diarrhea
• feeling of heat or flushing
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• red, burning, or itchy skin
• shortness of breath
• skin redness
• severe stomach or bowel pain
• blood in stool
• severe or persistent vomiting

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.