Instructions

This medicine is given as an IV injection into a vein.

This medicine should be given over 60 minutes.

This medicine should be given by a trained health care provider.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

May cause mouth sores. Brush teeth gently. Avoid products containing alcohol. Rinse mouth with a mixture of water and baking soda or salt.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Tell your doctor or nurse right away if you have dizziness, chest tightness, chills, shaking, fast heartbeat, or a feeling of heat or flushing while the medicine is being given. The medicine may need to be stopped or given at a slower rate.

Please check with your doctor before drinking alcohol while on this medicine.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine. You may safely start breastfeeding 2 months after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women must use reliable forms of birth control while taking this medicine and for 3 months after stopping to prevent pregnancy.

Always carry an ID card or wear a medical alert bracelet indicating your medical condition.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• diarrhea
• headaches
• mouth sores or irritation
• nausea and vomiting
• pain near injection site

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• severe or persistent abdominal pain
• severe back pain
• bleeding or bruising
• chest pain
• cough that does not go away
• coughing up blood or vomit that looks like coffee grounds
• dizziness
• swelling of the legs, feet, and hands
• nosebleeds
• fainting
• fever or chills
• pain, redness, swelling or blistering on hands, feet or elbows
• fast or irregular heart beats
• high blood pressure
• signs of kidney damage (such as change in urine color or bubbly urine)
• seizures
• shakiness
• shortness of breath
• skin tingling, burning or prickly feeling
• sore throat
• bloody or dark, tarry stools
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• unusual or unexplained tiredness or weakness
• blood in urine
• blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.