Instructions

This medicine is given as an IV injection into a vein.

This medicine should be given over 60 minutes.

Read and make sure you understand the instructions for measuring dose and using syringe. If you have any questions, talk to your doctor, nurse, or pharmacist.

The medicine needs to be mixed before being injected.

Follow package direction for diluting medicine with IV fluids or as instructed by your doctor or nurse.

Do not dilute the medicine until ready to use.

Always inspect the medicine before using.

The liquid should be clear and colorless.

Do not use the medicine if it contains any particles or if it has changed color.

Gently swirl to mix the medicine. Do not shake.

Keep medicine at room temperature. Protect from light.

Never use any medicine that has expired.

Discard any remaining medicine after your dose is given.

Wash your hands before and after handling this medicine.

Use this medicine at the same time each day.

Space doses evenly to keep a steady amount of medicine in the body.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Do not take the medicine more than once during 24 hours.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine is associated with a rare, but serious problem of the liver. Speak to your doctor about the early signs of liver problems and the benefits and risks of using this medicine.

Tell your doctor or nurse right away if fever, chills, severe dizziness, skin rash, itching, swelling, or difficulty breathing develop while the medicine is being given. The medicine may need to be stopped or given at a slower rate.

Do not use the medication any more than instructed.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Ask your pharmacist how to properly throw away used needles or syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• agitated feeling or trouble sleeping
• diarrhea
• headaches
• pain, redness, swelling near injection
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• feeling of heat or flushing
• fever or chills
• fast or irregular heart beats
• signs of kidney damage (such as change in urine color or bubbly urine)
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• mood changes
• shortness of breath

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.