Instructions

This medicine is for use in the rectum or around the anus. DO NOT take this medicine by mouth.

Use the applicator that is supplied with this medicine to insert the medicine into the anus.

Follow the instructions on the package to use this medicine correctly.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

Wash your hands before and after using this medicine. However, do not get up right away to wash your hands if you are supposed to lie down for a period of time to give the medicine time to work.

Fill the applicator with medicine. Gently insert the applicator into the anus, and push the plunger to put the medicine into the rectum.

Remove the applicator, take it apart, and wash the pieces in warm water.

Keep the medicine at room temperature. Avoid heat and direct light.

If using on the outside of the rectum, rub gently until the medicine is spread evenly.

Do not cover the area after applying medicine. Do not wear tight fitting diaper or plastic pants.

Avoid getting medicine in eyes, ears, nose or mouth. If medicine gets into one of these areas, rinse thoroughly with clean water.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal schedule. Do not take 2 doses at one time.

Tell your doctor if symptoms do not get better or if they get worse.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Do not use the medication any more than instructed.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• rectal burning or irritation

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding from rectum
• shallow, irregular breathing
• dizziness or drowsiness
• swelling of the legs, feet, and hands
• fever
• headaches
• fast, irregular, or slow heartbeat
• pale or blue skin, lips or fingernails
• red, burning, or itchy skin
• shortness of breath
• blood in stool
• unusual or unexplained tiredness or weakness
• blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.