Instructions

This medicine is given as an IV injection into a vein.

The liquid should be clear or light yellow.

This medicine should be given by a trained health care provider.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Tell your doctor or nurse right away if back, joint or chest pain; cough; dizziness; flushing, headache; nausea or vomiting; tiredness or weakness develop while the medicine is being given. The medicine may need to be stopped or given at a slower rate.

Contact your doctor if you notice a change in the amount or darkening of your urine.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

Contact your doctor immediately if you experience any swelling of your hands, face, lips, eyes, throat or tongue.

Always carry an ID card or wear a medical alert bracelet indicating your medical condition.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• coughing
• dizziness
• feeling of heat or flushing
• fever or chills
• pain in the joints
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• severe abdominal or pelvic pain
• back pain
• chest pain
• ear problems (ringing in the ears, hearing loss)
• swelling of the face, mouth, tongue, or throat
• hearing loss
• signs of kidney damage (such as change in urine color or bubbly urine)
• new or worsening movement problems
• eye pain or swelling
• redness of eyes
• shortness of breath
• unusual or unexplained tiredness or weakness
• inability to control urine or stool
• vaginal itching or yeast infection
• blurring or changes of vision
• severe or persistent vomiting

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.