Instructions

This medicine is given as an injection.

This medicine is given gradually through the IV line.

This medicine can make you sensitive to the sun. Use sunscreen or protective clothing when in sun.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

This medicine may cause serious bleeding problems in patients taking blood thinner medications. Follow your doctor's instructions carefully to monitor your blood lab tests if you are on blood thinners.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

To avoid a serious skin reaction, avoid heat and hot water. Also avoid pressure on elbows, knees, and feet. For example, avoid tight clothing, kneeling, or long walks.

Watch for excessive bruising or bleeding. Contact your doctor if you notice any.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Men and women should continue using birth control for at least 3 months after finishing this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• decreased appetite
• dry skin
• hair loss
• nausea and vomiting
• darkening of skin or nails

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• confusion
• coughing up blood or vomit that looks like coffee grounds
• diarrhea
• severe, watery or bloody diarrhea
• dizziness
• swelling of the legs, feet, and hands
• fever or chills
• pain, redness, swelling or blistering on hands, feet or elbows
• severe or persistent headache
• fast, irregular, or slow heartbeat
• mood changes
• mouth sores or irritation
• shortness of breath
• severe stomach or bowel pain
• dark, tarry stool
• difficulty swallowing
• unusual or unexplained tiredness or weakness
• blood in urine
• blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.