Instructions

This medicine may be taken with or without food.

This medicine will work best if you take it at about the same time every day.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

This medicine does not stop the spread of viruses that are passed through the blood or during sex.

Always use condoms during sex.

Do not share needles or other personal objects such as shavers or toothbrushes.

Do not take any medicine containing magnesium or aluminum (such as antacids, vitamins, quinapril, didanosine, sucralfate) for 6 hours before or 2 hours after this medicine.

If you take this medicine without food, do not take any medicine containing calcium or iron (such as antacids, vitamins) for 6 hours before or 2 hours after this medicine. If you take this medicine with food, you can take calcium or iron at the same time.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal schedule. Do not take 2 doses at one time.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep all appointments for medical exams and tests while on this medicine.

Do not take the medicine more than once during 24 hours.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine is associated with a rare, but serious problem of the liver. Speak to your doctor about the early signs of liver problems and the benefits and risks of using this medicine.

Do not use the medication any more than instructed.

Please check with your doctor before drinking alcohol while on this medicine.

Contact your doctor if you notice a change in the amount or darkening of your urine.

Contact your doctor if you develop any signs of a new infection such as fever, cough, sore throat, or chills.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

This medicine passes into breast milk. Because breast milk may transmit HIV, ask your doctor before breastfeeding.

Do not take St. John's wort while on this medicine.

Do not share this medicine with anyone who has not been prescribed this medicine.

Always refill this medicine before it runs out.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• agitated feeling or trouble sleeping
• headaches

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• depression or feeling sad
• swelling of the legs, feet, and hands
• fever or chills
• numbness or tingling in hands and feet
• hallucinations (unusual thoughts, seeing or hearing things that are not real)
• severe or persistent headache
• fast, irregular, or slow heartbeat
• irritability
• signs of kidney damage (such as change in urine color or bubbly urine)
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• mood changes
• tight or rigid muscles
• muscle weakness
• joint or muscle pain
• pale or blue skin, lips or fingernails
• rapid breathing
• shortness of breath
• red, peeling or blistering skin
• difficulty speaking
• difficulty swallowing
• swelling in the neck or throat
• unsteadiness while walking
• blurring or changes of vision
• severe or persistent vomiting
• unexpected or extreme weight loss

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.