Instructions

This medicine is given as an injection.

Carefully follow the instructions for preparing this medicine before injection.

If using the vial, do not remove the medicine from the vial until ready to use.

Do not mix this medicine with other solutions.

Check the medicine before each use. If the liquid medicine has any particles in it, appears discolored, or if the vial appears damaged, do not use it.

Do not shake the medicine before using.

Keep medicine in refrigerator. Do not freeze. Protect from light.

Keep the medicine in its original container.

Take the medicine out of the refrigerator about 30 minutes before use to warm to room temperature.

Never use any medicine that has expired.

Discard any remaining medicine after your dose is given.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

It may take several weeks for this medicine to fully work.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

You may need vitamin and mineral supplements while on this medicine. Please speak with your doctor or pharmacist.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

This medicine is associated with an increased risk of blood clots, heart attack, and stroke. Contact your doctor immediately if you experience leg pain or swelling, difficulty breathing, chest or jaw pain, severe headache, one-sided weakness or slurred speech.

Do not use the medication any more than instructed.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

If you have had a heart attack or a stroke within the past 6 months, talk to your doctor before using this medicine.

Ask your pharmacist how to properly throw away used needles or syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• bone pain
• coughing
• diarrhea
• swelling of the face, mouth, tongue, or throat
• headaches
• high blood pressure
• pain, redness, swelling near injection
• muscle pain
• nausea
• sore throat
• stomach pain

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• loss of balance
• chest or jaw pain
• weakened heart; fluid in lungs
• swelling of the legs, feet, and hands
• fainting
• severe or persistent headache
• fast or irregular heart beats
• sudden leg pain, swelling, warmth or redness
• pale or blue skin, lips or fingernails
• seizures
• shortness of breath
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• unusual or unexplained tiredness or weakness
• blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.