Instructions

This medicine will be given to you at the hospital or infusion center.

This medicine is given as an IV injection into a vein.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

It is very important that you follow your doctor's instructions for all blood tests.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Tell your doctor or nurse right away if fever, chills, dizziness, feeling of heat or flushing, itching or shortness of breath develop while the medicine is being given. The medicine may need to be stopped or given at a slower rate.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Please check with your doctor before drinking alcohol while on this medicine.

Do not breastfeed while on this medicine. You may safely start breastfeeding 1 month after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women must use reliable forms of birth control while taking this medicine and for 1 month after stopping to prevent pregnancy.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• decreased appetite
• diarrhea
• dizziness
• lack of energy and tiredness
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• chest pain
• severe, watery or bloody diarrhea
• swelling of the legs, feet, and hands
• eye pain or redness
• fever
• fast, irregular, or slow heartbeat
• signs of kidney damage (such as change in urine color or bubbly urine)
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• mouth sores or irritation
• muscle weakness
• joint or muscle pain
• sensitivity to light
• shortness of breath
• red, peeling or blistering skin
• severe stomach or bowel pain
• bloody or dark, tarry stools
• excessive thirst
• increased urinary frequency
• blurring or changes of vision
• sudden or unexplained change in weight

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.