Instructions

This medicine is given as an injection.

This medicine is given gradually through the IV line.

Read and make sure you understand the instructions for measuring dose and using syringe. If you have any questions, talk to your doctor, nurse, or pharmacist.

The medicine needs to be mixed before being injected.

Follow package direction for diluting medicine with IV fluids or as instructed by your doctor or nurse.

Do not dilute the medicine until ready to use.

Check the medicine before each use. If the liquid medicine has any particles in it, appears discolored, or if the vial appears damaged, do not use it.

Keep this medicine in the refrigerator. Do not freeze.

Never use any medicine that has expired.

Discard any remaining medicine after your dose is given.

Speak with your nurse or pharmacist about how long the unused, mixed medicine can be stored safely in the refrigerator before it needs to be discarded.

This medicine should only be used by a person who has been trained to recognize when and how it should be used.

Wash your hands before and after handling this medicine.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Do not take the medicine more than once during 24 hours.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine is associated with a rare, but serious problem of the liver. Speak to your doctor about the early signs of liver problems and the benefits and risks of using this medicine.

Tell your doctor or nurse right away if fever, chills, dizziness, feeling of heat or flushing, itching or shortness of breath develop while the medicine is being given. The medicine may need to be stopped or given at a slower rate.

Do not use the medication any more than instructed.

Call the doctor if there are any signs of confusion or unusual changes in behavior.

Family should check on the patient often. Call the doctor if patient becomes more depressed, has thoughts of suicide, or shows changes in behavior.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Ask your pharmacist how to properly throw away used needles or syringes.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• agitated feeling or trouble sleeping
• diarrhea
• headaches
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• dizziness
• swelling of the legs, feet, and hands
• feeling of heat or flushing
• fever or chills
• pain, redness, swelling or blistering on hands, feet or elbows
• fast or irregular heart beats
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• mood changes
• muscle cramps or weakness
• shortness of breath

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.