Instructions

This medicine is given as an IV injection into a vein.

This medicine should be given over 60 minutes.

This medicine should be given by a trained health care provider.

You must be monitored by a health care professional during and after each dose is given.

This medicine can make you sensitive to the sun. Use sunscreen or protective clothing when in sun.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine is associated with an increased risk of serious heart problems, heart attack, and stroke. Please speak with your doctor about the risks and benefits of using this medicine. Contact your doctor immediately if you experience chest pain or difficulty breathing.

Tell your doctor or nurse right away if fever, chills, severe dizziness, or shortness of breath develop while the medicine is being given. The medicine may need to be stopped or given at a slower rate.

Do not breastfeed while on this medicine. You may safely start breastfeeding 3 months after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women must use reliable forms of birth control while taking this medicine and for 3 months after stopping to prevent pregnancy.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• diarrhea
• headaches
• nausea and vomiting
• dry skin
• stomach upset or abdominal pain
• weight loss

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• chest or jaw pain
• dizziness
• fainting
• severe or persistent headache
• sudden leg pain, swelling, warmth or redness
• muscle pain
• red, burning, or itchy skin
• shortness of breath
• red, peeling or blistering skin
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• difficulty swallowing
• excessive or unusual sweating
• sudden change or loss of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.