Instructions

This medicine is given as a continuous infusion into the spine.

Read and make sure you understand the instructions for preparing the medicine and using the infusion pump. If you have any questions, talk to your doctor, nurse, or pharmacist.

Always inspect the medicine before using.

The liquid should be clear and colorless.

Do not use the medicine if it contains any particles or if it has changed color.

Keep this medicine in the refrigerator. Do not freeze.

Never use any medicine that has expired.

Discard any unused, mixed medicine after 24 hours in refrigerator.

Wash your hands before and after handling this medicine.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

You or a family member can be trained to give this medicine at home.

Learn how to use the infusion pump and what the pump alarm sounds like. If you hear the alarm, contact the doctor right away.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep all appointments for medical exams and tests while on this medicine.

Do not take the medicine more than once during 24 hours.

Cautions

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

This medicine may cause dizziness or fainting. Do not stand or sit up quickly.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

If possible, avoid using with alcohol, marijuana, or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

Call the doctor if there are any signs of confusion or unusual changes in behavior.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

Ask your doctor, nurse or pharmacist how to safely discard unused medicines, needles and syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• dizziness or drowsiness
• headaches
• nausea
• weakness

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• decreased awareness or responsiveness
• loss of balance
• changes in memory, mood, or thinking
• confusion
• depression or feeling sad
• high fever
• hallucinations (unusual thoughts, seeing or hearing things that are not real)
• numbness or tingling in hands and feet
• severe or persistent headache
• pain, redness, swelling near injection
• pus at injection site
• memory problems or loss
• muscle pain
• neck pain or stiffness
• sensitivity to light
• difficulty speaking
• suicidal thoughts
• difficulty swallowing
• unsteadiness while walking
• difficulty or discomfort urinating
• dark urine
• vomiting

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.