Instructions

This medicine is given as an IV injection into a vein.

Carefully follow the instructions for preparing this medicine before injection.

Always inspect the medicine before using.

The liquid should be clear and colorless.

Do not use the medicine if it contains any particles or if it has changed color.

Some brands of this medicine must be stored in the refrigerator while others may be kept at room temperature. Please speak with your pharmacist about how you should store your medicine.

Keep the medicine in its original container.

Protect medicine from light.

Speak with your nurse or pharmacist about how long the medicine can be stored safely at room temperature or in the refrigerator before it needs to be discarded.

Never use any medicine that has expired.

Wash your hands before and after handling this medicine.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

Drink plenty of water while on this medicine.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Visit your dentist regularly. Proper care of your teeth is very important while taking this medicine. Brush your teeth and floss regularly.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Do not use the medication any more than instructed.

This medicine may cause dizziness or fainting. Do not stand or sit up quickly.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Please check with your doctor before drinking alcohol while on this medicine.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

This medicine can cause birth defects. Speak with your doctor about birth control methods that should be used while on this medicine.

Ask your doctor, nurse or pharmacist how to safely discard unused medicines, needles and syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• agitated feeling or trouble sleeping
• decreased appetite
• bone pain
• diarrhea
• drowsiness or sedation
• lack of energy and tiredness
• fever or chills
• pain, redness, swelling near injection
• joint or muscle pain
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• confusion
• eye pain or redness
• fast or irregular heart beats
• irritability
• jaw pain
• signs of kidney damage (such as change in urine color or bubbly urine)
• mouth sores or irritation
• muscle aches, spasms or abnormal movements
• feeling of numbness or tingling, especially around the lips and mouth
• unusual or unexplained pain in hips, thighs or groin
• eye pain or swelling

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.