Instructions

This medicine is given as an IV injection into a vein.

Carefully follow the instructions for preparing this medicine before injection.

Read and make sure you understand the instructions for measuring your dose and using the syringe before using this medicine.

Dilute the powder with the liquid provided. Gently swirl the vial until the medicine is completely dissolved. Do not shake the vial.

Do not dilute the medicine until ready to use.

Always inspect the medicine before using.

Do not use the medicine if it is cloudy, contains flakes or large particles, or if it has changed color.

Some brands of this medicine must be stored in the refrigerator while others may be kept at room temperature. Please speak with your pharmacist about how you should store your medicine.

If your medicine is stored in the refrigerator, take it out of the refrigerator before use to warm to room temperature.

Inject the medicine immediately after mixing.

Injecting cold drug may be uncomfortable.

Speak with your nurse or pharmacist about how long the medicine can be stored safely at room temperature or in the refrigerator before it needs to be discarded.

Please ask your doctor, nurse, or pharmacist how to discard unused medicines safely.

If using this medicine at home, ask your doctor, nurse, or pharmacist to show you or a family member how to use this medicine correctly.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Do not use the medication any more than instructed.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

Always carry an ID card or wear a medical alert bracelet indicating your medical condition.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• feeling of heat or flushing
• fever or chills
• headaches
• pain, redness, swelling near injection
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• chest pain
• swelling of the legs, feet, and hands
• blue coloring of hands or feet
• signs of kidney damage (such as change in urine color or bubbly urine)
• sudden leg pain, swelling, warmth or redness
• pale or blue skin, lips or fingernails
• rapid heartbeat
• shortness of breath
• unusual or unexplained tiredness or weakness
• dark urine
• severe or persistent vomiting
• yellowing of eyes or skin

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.