Instructions

This medicine is given as an injection into a muscle.

Read and make sure you understand the instructions for measuring dose and using syringe. If you have any questions, talk to your doctor, nurse, or pharmacist.

The medicine needs to be mixed before being injected.

Dilute the powder with the liquid provided. Gently swirl the vial until the medicine is completely dissolved. Do not shake the vial.

Do not dilute the medicine until ready to use.

Always inspect the medicine before using.

The liquid should be clear and colorless.

Do not use the medicine if it contains any particles or if it has changed color.

Keep at room temperature until mixing. Refrigerate any extra mixed medicine until ready to use it.

Do not store above 77 degrees F (25 degrees C).

Protect medicine from light.

If your medicine is stored in the refrigerator, take it out of the refrigerator about 15 minutes before use to warm to room temperature.

Return multi-dose vials to refrigerator after each use.

Injecting cold drug may be uncomfortable.

Speak with your nurse or pharmacist about how long the medicine can be stored safely at room temperature or in the refrigerator before it needs to be discarded.

Never use any medicine that has expired.

Wash your hands before and after handling this medicine.

You or a family member can be trained to give this medicine at home.

Do not inject into skin that is red, swollen or itchy.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine is associated with an increased risk for serious blood clots. Speak with your doctor about the benefits and risks from using this medicine.

Do not use the medication any more than instructed.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

Do not use this medicine if you are pregnant. If you become pregnant, contact your doctor immediately.

If you have had a heart attack or a stroke within the past 6 months, talk to your doctor before using this medicine.

Ask your doctor, nurse or pharmacist how to safely discard unused medicines, needles and syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• lack of energy and tiredness
• headaches
• pain, redness, swelling near injection
• multiple babies during pregnancy
• restlessness
• weight gain

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• severe abdominal or pelvic pain
• bloating
• breast pain or swelling
• chest or jaw pain
• depression or feeling sad
• feeling of swelling of the body
• swelling of the legs, feet, and hands
• severe or persistent headache
• irritability
• sudden leg pain, swelling, warmth or redness
• signs of early puberty in boys (e.g., pubic/facial hair, voice changes, acne)
• shortness of breath
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• urinating less often
• vaginal bleeding or spotting between periods
• sudden change or loss of vision
• severe or persistent vomiting
• sudden or unexplained weight gain

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.