Instructions

This medicine is given as an IV injection into a vein.

This medicine should be given over 1 to 2 hours.

Carefully follow the instructions for preparing this medicine before injection.

Always inspect the medicine before using.

The liquid should be clear.

Do not use the medicine if it contains any particles or if it has changed color.

Keep medicine at room temperature. Protect from light.

Never use any medicine that has expired.

Discard any remaining medicine after your dose is given.

Discard any unused, mixed medicine after 24 hours in refrigerator.

Space doses evenly to keep a steady amount of medicine in the body.

Ask your doctor, nurse or pharmacist to show you how to use this medicine correctly.

You or a family member can be trained to give this medicine at home.

This medicine can make you sensitive to the sun. Use sunscreen or protective clothing when in sun.

Tell your doctor if you have severe or persistent sweating, diarrhea or vomiting. These can increase your risk of a serious side effect.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

It is very important that you follow your doctor's instructions for all blood tests.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

Tell your doctor or nurse right away if any of these happen while the medicine is being given: fever, chills, feeling of heat or flushing, dizziness, fainting, nausea, or shortness of breath. The medicine may need to be stopped or given at a slower rate.

Do not use the medication any more than instructed.

Do not drink beverages with alcohol while on this medicine.

Do not breastfeed while on this medicine.

This medicine can cause birth defects. Speak with your doctor about birth control methods that should be used while on this medicine.

Ask your doctor, nurse or pharmacist how to safely discard unused medicines, needles and syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• headaches
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• bone pain
• dizziness
• swelling of the legs, feet, and hands
• pain in the eye
• fainting
• fever
• swelling in the neck or throat
• hallucinations (unusual thoughts, seeing or hearing things that are not real)
• fast or irregular heart beats
• pain in the joints
• signs of kidney damage (such as change in urine color or bubbly urine)
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• mood changes
• sensitivity to light
• red, peeling or blistering skin
• change in the size or color of a skin mole
• blurring or changes of vision
• vision problems - changes in seeing color
• severe or persistent vomiting

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.