Instructions

This medicine is given as an IV injection into a vein.

Carefully follow the instructions for preparing this medicine before injection.

The liquid should be clear and colorless.

Check the medicine before each use. If the liquid medicine has any particles in it, appears discolored, or if the vial appears damaged, do not use it.

Do not shake the medicine before using.

Store new medicine in the refrigerator until you are ready to use it. Do not allow them to freeze.

Keep the medicine in its original container.

If the medicine becomes frozen, you will need to throw it away.

Protect medicine from light.

Take the medicine out of the refrigerator about 30 minutes before use to warm to room temperature.

Discard any remaining medicine after your dose is given.

This medicine should be given by a trained health care provider.

Drink plenty of water while on this medicine.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

During pregnancy, this medicine should be used only when clearly needed. Talk to your doctor about the risks and benefits.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

This medicine is associated with an increased risk of blood clots, heart attack, and stroke. Contact your doctor immediately if you experience leg pain or swelling, difficulty breathing, chest or jaw pain, severe headache, one-sided weakness or slurred speech.

Do not use the medication any more than instructed.

Contact your doctor if you develop any signs of a new infection such as fever, cough, sore throat, or chills.

Wash your hands often and avoid close contact with people with infections such as colds and flu.

Speak with your health care provider before receiving any vaccinations.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

Ask your doctor, nurse or pharmacist how to safely discard unused medicines, needles and syringes.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• coughing
• diarrhea
• feeling of heat or flushing
• fever or chills
• headaches
• pain, redness, swelling near injection
• pain in the joints
• muscle cramps
• nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• bleeding or bruising
• rapid breathing
• chest or jaw pain
• pain in the eye
• fainting
• severe or persistent headache
• sudden leg pain, swelling, warmth or redness
• neck pain or stiffness
• pale or blue skin, lips or fingernails
• rapid heartbeat
• sensitivity to light
• shortness of breath
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• unusual or unexplained tiredness or weakness
• increased urinary frequency
• urinating less often
• dark urine
• sudden or unexplained weight gain
• yellowing of eyes or skin

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.